Sperm DNA fragmentation testing evaluates the degree of damage to genetic information in sperm. It is a supplementary test to a standard semen analysis and provides doctors with additional important information for correctly setting up treatment.
A standard semen analysis assesses sperm count, motility and morphology. However, these values do not always reveal sperm quality in detail. In some cases, semen analysis can therefore be extended with sperm DNA fragmentation testing, which provides a deeper insight into sperm quality.
Sperm DNA fragmentation testing helps estimate the proportion of sperm in the ejaculate that have damaged DNA. Even sperm that appear normal at first glance may have fragmented DNA, which can make conception more difficult or affect the further course of pregnancy.
At our clinic, we perform DNA fragmentation testing using the SCD method. Special chemical substances are used to loosen and visualise the DNA in sperm. If the DNA is undamaged, a characteristic “halo effect” forms around the sperm head.
This test therefore shows what percentage of sperm in the sample have damaged DNA. This information helps the doctor choose the next treatment steps more precisely.
Sperm DNA fragmentation testing is particularly useful in cases of repeated treatment failures or recurrent spontaneous miscarriages. A major advantage is that no additional sample collection is needed – the test can be performed from the same ejaculate sample as the standard semen analysis.
DNA fragmentation means damage to the genetic information carried by sperm.
A standard semen analysis assesses sperm count, motility and morphology. DNA fragmentation testing focuses on the quality of the genetic information inside the sperm, which a standard examination does not evaluate.
The result helps the doctor choose the next treatment steps more precisely, such as lifestyle changes, antioxidant supplementation, shortening the abstinence period before sample collection or selecting a suitable assisted reproduction method.
Hlinky 144, 603 00 Brno, CZ
Hlinky 144, 603 00 Brno, CZ
