KIR and HLA-C testing is a genetic blood test that evaluates the mutual "immune communication" between the mother and the embryo. It helps determine whether the woman's immune system may negatively affect embryo implantation or the course of pregnancy. The result provides doctors with information for choosing further treatment, especially in cases of repeated IVF failures or recurrent miscarriages.
KIR and HLA-C are genetic markers that influence the mutual communication between the woman's immune system and the developing embryo.
KIR are receptors present on the surface of so-called NK cells, meaning natural killer cells, in the uterine lining. These cells play an important role in embryo implantation and placenta formation.
HLA-C are markers found on the surface of embryo cells, specifically in the trophectoderm, the part of the embryo from which the placenta later develops.
The proper interaction between the mother's KIR receptors and the embryo's HLA-C markers, especially those inherited from the father, supports successful implantation and the normal course of pregnancy. If this communication is less favourable, it may contribute to repeated IVF failures or miscarriages.
KIR B haplotype (Bx) in woman
Embryo with HLA-C1/C1 or C1/C2
These combinations are generally considered more favourable for embryo implantation.
KIR AA haplotype in woman
Embryo with HLA-C2/C2 or C1/C2 (especially if C2 is inherited from the father)
This combination may be associated with a lower chance of successful embryo implantation and a higher risk of certain pregnancy complications.
The test helps doctors better understand possible immunological factors and choose a suitable treatment approach. It is important to emphasise that these are not "good" or "bad" genes – only different natural variants that may influence the course of pregnancy. The result is always assessed individually in the context of the couple's overall health and reproductive history.
Hlinky 144, 603 00 Brno, CZ
Hlinky 144, 603 00 Brno, CZ
